The Department of Glaucoma Service (the Glaucoma Center) at ZOC was established by Prof. Wenbing Zhou, the founder of the Chinese Glaucoma Society (CGS) in 1950’s. As the earliest specialized department of glaucoma service in China，numbers of illustrious glaucoma experts (Profs. Tiancai Ye, Meili Zhang, Dawei Peng, Shouxiong Peng, et al.) were trained and established here. The Glaucoma Center has always been recognized as one of the leading institutions all over China due to its leading technology in glaucoma diagnosis and treatment. Under the guidance of academic leaders such as Prof. Jian Ge (the first chief scientist of the “National Key Basic Research Program of China (973 Program)” and Honorary Chairman of the Chinese Ophthalmological Society (COS)), Prof. Minbin Yu (Deputy Chairman of COS, Deputy Secretary of the CPC of Sun Yat-sen University) and the department director, Prof. Mingkai Lin, an extinguished team has been well established. Besides, Profs. Yehong Zhuo, Xing Liu and Xiulan Zhang have been playing crucial academic influence. The team of glaucoma center is now investigating the comprehensive and cutting-edge fields in clinical and scientific research, such as pathogenesis, early diagnosis, individualized treatment and precisely-targeted intervention, treatment for refractory and complicated glaucoma, neuroprotection, stem cell therapy, et al. The department initiated the first edition of the Diagnosis and Staging Criteria of Primary Angle-Closure Glaucoma (PACG) in China (1984) and following editions of Glaucoma Guidelines and Expert Consensus in China since 1987. As the leading institution for complicated and refractory glaucoma service in China, the department manages an annual workload of 45,000 outpatients (non-local cases over 70%), 3,000 inpatients and over 3,500 surgeries. 

Leading by Prof. Mingkai Lin (Director), Prof. Xing Liu (Senior Consultant), and Prof. Zhigang Fan (Deputy Director), there are 8 professors, 4 associate professors, 8 attending doctors, 1 deputy director nurse and 1 deputy chief technician are now serving in the department, which is now the Key Specialty of Guangdong Province. Numbers of founding supports have been obtained during recent years, including National Natural Science Foundation of China (25 projects), National High Technology Research and Development Program of China (873 Program, 1 project), Key Clinical Projects of the Ministry of Health of China (1 project), Natural Science Foundation of Guangdong Province (over 30 projects), Science Foundation of Bureau level (over 10 projects), and International Cooperation Project (3 projects). In 2010, Glaucoma Center received the second prize of National Scientific and Technology Advance Award by the State Council of China. As the chief editor, we’ve published 3 textbooks of ophthalmology and other monographs, such as 《Clinical Glaucoma》, 《Selected Simulated Tests for Ophthalmology》and《Optical Coherence Tomography in Clinical Ophthalmology》(awarded Guangdong Province excellent science and technology monograph publishing fund) et al. Over 300 academic peer-reviewed papers (over 250 SCI) were published. 

The Glaucoma Center has 8 doctoral supervisors and 4 master supervisors, training more than 20 master and doctoral graduates every year. As for clinical training, there are more than 50 doctors trained in a continuous education program annually. It’s also the largest and major Standardized Training Base for domestic ophthalmologists and glaucoma specialty fellows. In 2010, Patients’ Club for Glaucoma, titled “Glaucoma Home”, was established, serving for educational programs, volunteer consultations, enhancing communication between doctors and patients, and popularization of glaucoma related knowledges. 

Faculty    

Jian Ge Ph. D., MD.  

·Member of standing committee of the Asia Pacific Glaucoma Society 

·Honorary Chairman of the Chinese Ophthalmologic Society 

·Vice chairman of the Chinese Eye Doctor Association 

·Former Chairman of the Chinese Glaucoma Society 

·Honorary Lifetime Director of State Key Laboratory of Ophthalmology 

·Chairman of Guangdong Eye Doctor Association 

·Member of standing committee of the Evidence-based medicine committee of the Chinese doctor association 

·Editor-in-chief of “Eye Science” and“Molecular Vison” 

·Vice editor-in-chief of “Chinese Journal of Ophthalmology” and “Chinese Journal of Experimental Ophthalmology” 

Teaching Experience：  

Supervisor of 74 Ph.Ds and 8 post-dortoral fellows. 

Research:  

Prof. Ge’s research covers many aspects of ophthalmology and vision research, ranging from basic science to clinical fields. The followings have been involved: (1) Mechanism of experimental myopia in rhesus monkeys; (2) Gene screen and function in familial primary open angle glaucoma; (3) Stem cell and regeneration, iPS and tissue engineering in ophthalmology; (4) Wound healing and modulation of scar formation after glaucoma surgery; (5) New alternatives in the treatment of glaucoma, special interest in Phaco, Shunt, Laser therapy. 

Professor Ge get the big government funding , including The National Basic Research Program of China (973 Program) for the pathogenesis and management for irreversible blindness eye diseases. 

And the Key project of national natural science funding for the stem cell and tissue engineering therapy for the irreversible blindness. 

Minbin Yu M.D. & Ph.D.  

Prof. Yu was rewarded the outstanding young and middle-aged expert by the Ministry of Health and he is the expert to enjoy the special government allowances issued by the State Council. He is currently Deputy Secretary of the CPC of Sun Yat-sen University who heads the Department of Glaucoma at Zhongshan Ophthalmic Center, Sun Yat-sen University. He is the expert member of the Chinese medical association, deputy chairman of glaucoma, vice chairman of Guangdong medical association, and deputy chairman of ophthalmology department. He is the editorial board member of Chinese Journal of Ophthalmology, Chinese Journal of Optometry Ophthalmology & Visual Science, International Review of Ophthalmology and Chinese Journal of Ophthalmology and Otorhinolaryngology. And he is also the associate editor of Eye Science. 

Prof. Yu has been devoting his efforts to investigating early diagnosis and treatment of glaucoma, surgery of refractory glaucoma and congenital glaucoma.Prof. Yu took the lead application of endoscopic surgery in ophthalmology, and has completed nearly 10,000 cases of glaucoma surgery. With his leadership, his team made an important contribution to the investigation of visual function application in glaucomatic patients and new anti-scar medication, and mechanism of binocular visual function in amblyopia. Dr. Yu was in charge of national research grants, the Ministry of Science and Technology of China， national research grants of Guangdong Province. He has published over 100 papers, including 47 peer-reviewed SCI papers as the first author or corresponding author, among which was published on Current Biology, Ophthalmology, IOVS, Scientific Report, Medicine. He has received successively third Prize of Guangdong Science and Technology Progress Awards in 2000, second Prize of Guangdong Science and Technology Progress Awards. in 2009, prize of chinese society of ophthalmology, Nan Yue outstanding teachers, excellent teacher of Sun Yat-sen University, and famous doctors of Sun Yat-sen University. 

Yehong Zhuo M.D., Ph.D.  

Dr. Zhuo received his MD (1989) and PhD (1999) from Sun Yat-sen University of Medical Science, and did postdoctoral fellowship at Yale University (2003-2005). He joined Zhongshan Ophthalmic Center (ZOC) in 1989, where he is currently a Professor of Ophthalmology and Vice President. He serves as the Committee Board Member of the Chinese Ophthalmological Society and the Glaucoma Group, Vice Chairman of the Guangdong Ophthalmological Society, and the editorial board member of the Chinese Medical Journal (English Edition) and the Chinese Journal of Ophthalmology, and has served on review committees for the National Natural Science Foundation of China (NNSFC). 

As a physician scientist, Dr. Zhuo has engaged in ophthalmologic clinical work, research and education for almost three decades, and has redundant clinical experience in early diagnosis, medical and surgical therapy for glaucoma. He is the leading pioneer in China for glaucoma genetic research, glaucoma drainage valve implantation surgery, establishing experimental glaucoma model and stem cell transplantation therapy in primates, and building platform for translational research of glaucoma. Numbers of founding supports were obtained: National Natural Science Foundation of China (4 projects), Ministry of Education of China (2 projects), Major Research Cultivation Program (1 project) and Key Program (1 project) of the Guangdong Province Natural Science Foundation, etc. As the first /corresponding author, he has published 62 peer-reviewed articles, including 32 SCI papers (total IF 125.6). He was named the "National Top 100 Excellent Doctoral Dissertations Award (2003)" and his research was awarded the "National Top 10 Progresses in Glaucoma Research (2013)". He received the “2nd Prize of National Science and Technology Progress Award”, the “1st Prize of Science and Technology Progress Award: Ministry of Education”, the “1st Prize of Science and Technology Progress Award: Guangdong Province”, the "Ding Ying Science and Technology Award: Guangdong Province”, the “Leading Talent Awards of Guangdong Tezhi Plan”, “The Best Doctors of Guangzhou”, etc. 

Xing Liu, M.D., Ph.D.  

Prof. Liu is an experienced glaucoma surgeon and has been a member of the Zhongshan Ophthalmic Center since 1983. She is one of the earliest physician scientists in China using optical coherence tomography for retinal imaging and early glaucoma diagnosis. Her clinical interests also include the surgical treatment of complicated or refractory glaucoma and pediatric glaucoma especially those with complicated congenital dysplasia. In recent years, her outpatient volume and surgery volume rank No. 1 in Department of Glaucoma, Zhongshan Ophthalmic Center. She was selected as one of the “Best Female Doctors in China” and the "Best Doctors in Guangzhou". 

Prof. Liu’s recent research interests include the effects of glaucoma medications and surgeries on ocular surface, effects of different surgeries in primary congenital glaucoma, pathogenesis of lens-induced glaucoma, and pathological gene detection of primary angle-closure glaucoma. In collaboration with oversea scientists, she is also investigating on the morphological and functional changes of early stage age-related macular degeneration. Prof. Liu has published over 300 academic papers, including over 40 SCI papers, including American journal of ophthalmology, IOVS, and Retina et al. She is the chief editor of the book《Optical Coherence Tomography in Clinical Ophthalmology》,《Selected Simulated Tests for Ophthalmology》,《Ophthalmic Surgery》, and 《Clinical Glaucoma》. 

Prof. Liu has received nearly 20 scientific supports. As a chief member, she received the second prize of National Scientific and Technology Advance Award by the Ministry of Science and Technology of China and the first prize of Scientific & Technological progress award from Education Committee of China, Ministry of Health Science and Technology Achievement Award, Science and Technology Progress Award of Guangdong Province, Health Office science and Technology Achievement Award of Guangdong Province, and Science and Technology Award of Guangzhou. 

Mingkai Lin, M.D., Ph.D.  

Dr. Lin received his MD (1998) and PhD (2001) from Sun Yat-sen University, and did postdoctoral fellowship (2002-2003) at optometry school in University of California, Berkeley, and being as a visiting scholar in University of Oklahoma (2009-2010). 

Dr. Lin has engaged in ophthalmologic clinical work, research and education for almost twenty years. He has received over ten scientific grants as principal investigator, including National Natural Science Foundation of China. Dr. Lin has published excellent original articles in international and Chinese peer-reviewed journals as first author, the highest IF of which reached 6.97. As a chief member, Dr. Lin received the second prize of National Scientific and Technology Advance Award by the Ministry of Science and Technology of China. 

Dr. Lin has rich clinical experience in early diagnosis, medical and surgical therapy for glaucoma. Dr. Lin’s clinical interest focuses on the treatment of refractory glaucoma, and his research focuses on filtration passage scarring of glaucoma surgery. Notably, Dr. Lin has expertise in making personalized treatment for individuals via comprehensive application of modern advancements and traditional means. 

Xiulan Zhang C.V  

Prof. Xiulan Zhang, MD, PhD, glaucoma specialist, is currently the director of the Clinical Research Center at Zhongshan Ophthalmic Center (ZOC), Sun Yet-sen University in Guangzhou, China. She is the outstanding PI of State Key Laboratory of Ophthalmology in China and the fellow of the Academy of Asia-Pacific Professors of Ophthalmology (AAPPO). She serves as a council member of the Chinese Neuro-Ophthalmology Society, the secretary of the Chinese Glaucoma Society, the deputy secretary and Standing Committee member of the China International Exchange and Promotion Association for Medical and Healthcare’s Ophthalmological Academy, and the board member of the Asia Angle-Closure Glaucoma Club (AACGC). She was listed as one of the Top 100 influential people in ophthalmology in 2014 and received the Achievement Award of Asia-Pacific Academy of Ophthalmology (APAO) in 2017. She is also the Convener of the Glaucoma Scientific Program of APAO Congress 2018. 

Prof. Zhang has been engaged in clinical practice, teaching and research of ophthalmology for 29 years. Her main interest of research includes clinical and basic science of glaucoma including imaging studies. She has received 24 scientific grants as PI including 5 National Natural Science Foundation of China. She published 200 articles in international and Chinese peer-reviewed journals, which contains 106 SCI articles including Lancet, Ophthalmology and IOVS. Prof. Zhang has authored and published two books, including Illustrated Surgical Techniques and Pearls of Glaucoma (2016), Illustrated Clinical Diagnosis and Treatment of Glaucoma (2014), Both two books are the best seller and got highest award of the year in Ophthalmology of the People’s Medical Publishing House. She also published the translated version of Children Glaucoma WGA Consensus Series and other 7 book chapters. She serves as an editorial board member of more than 10 Ophthalmology journals and a reviewer for more than 10 peer-reviewed journals including Ophthalmology, IOVS, PLoS One, Br J Opthalmol, Acta Ophthalmologica, Molecular Vision and Journal of Ocular Pharmacology and Therapeutics. She has received a number of prestigious awards including second prize of 2017 Guangdong Science and Technology Progress Award , first prize of 2009 Science & technology Development/Achievement of the Ministry of Education, and 2010 National Science and Technology Progress Award (6th contributor). She is the only one that has been rated as outstanding teacher of Zhongshan Ophthalmic Center for 10 consecutive years. She has cultivated 23 masters and doctors and given invited lectures for 362 times around domestic and international countries. 

International Communication  

1. Positions and awards: Prof. Xiulan Zhang was listed as one of the TOP 100 influential people in ophthalmology in 2014. She was awarded the Achievement Award of Asia-Pacific Academy of Ophthalmology (APAO) in 2017. She is the fellow of the Academy of Asia-Pacific Professors of Ophthalmology (AAPPO) and the board member of the Asia Angle-Closure Glaucoma Club (AACGC). She also serves as the Convener of the Glaucoma Scientific Program of APAO Congress 2018. 

2. Invited lectures：So far, she has been invited to give lectures for 110 times in international countries including at international ophthalmology congresses such as AAO, ARVO, WOC, WGC, APGC, APAO, etc. 

3. International cooperation: She has broad cooperation with various international ophthalmology insitutes, including University of Pennsylvania USA, Heidelberg University Germany, University of Murcia Spain, Singapore National Eye Institute in conduction of projects or multi-center clinical trials. 

Zhigang Fan  

Professor, doctor of medicine, doctoral supervisor, one of top Chinese scientists from the 100-Talent Program of Sun Yat-sen University, the PI of State Key Laboratory of Ophthalmology, the deputy director of glaucoma department in Zhongshan Ophthalmic Center. 

Prof. Fan, having more than 10 years of ophthalmology clinical experience in China and more than 10 years of experimental research experience in Harvard University, is committed to solve the clinical problem using the basic study. He was principal investigator in Berth Israel Deaconess Medical Center affiliated to Harvard University, conducting many research of NIH, and obtaining the JDRF Advanced fellowship. Now his major research area are neurodegeneration in visual system diseases, nerve regeneration and regulation of immune inflammation. Additionally, he has published many original articles at international top medical journals such as Nature Medicine (IF=28.05) and PNAS (IF=9.66). 

Ling Yunlan  

Associate chief physician, supervisor of postgraduate,has engaged in the ophthalmology for three decades. Specializes in all kinds of diagnosis, drug and surgical treatment of glaucoma, has certain clinical experience in the diagnosis and treatment in refractory and complexity glaucoma，and has done some research on the clinical application of the optical coherence tomography (OCT) and retina tomography (HRT) . 

Jingjing Huang, MD, PhD  

Prof. Huang is a chief attending ophthalmologist and professor in Zhongshan Ophthalmic Center (ZOC), Sun Yat-sen University. She has been working as an ophthalmologist since 1997. 

As a clinical doctor, Prof. Huang provides more than 6000 outpatient service and more than 400 inpatient service a year, and performs more than 500 intraocular operations a year. As a professor, she is the tutor of postgraduates, undergraduates and residents. In addition, she is the teaching advisor in ZOC and in charge of residency training program. As a clinical scientist, her research focuses on neuroprotection and ophthalmic imaging, especially on glaucoma. She has published over 70 articles in professional journals (including Ophthalmology, IOVS, Retina, Journal of Glaucoma, Journal of Neurochemistry, Molecular Neurobiology, etc), and more than 10 chapters in professional monograph. She is the principal investigator of 11 research projects on ophthalmology, including 2 projects from Natural Science Foundation of China, 2 projects from Natural Science Foundation of Guangdong Province, etc. 

Yimin Zhong  

MD, PhD is Associate Professor of Ophthalmology in Department of Glaucoma. Zhong obtained her M.D. and Ph.D. in Ophthalmology from Sun Yat-sen University. She completed her residency and fellowship at Zhongshan Ophthalmic Center. Dr Zhong`s clinical and research focuses are on effects of glaucoma filtering surgery and anti-metabolic drugs on ocular surface, pathogenesis of primary open angle glaucoma, childhood glaucoma, diabetic retinopathy and age-related macular degeneration. She was the principle investigator of several grants, including the national natural science foundation for young scientists, the special fund for doctoral programs in universities, the natural science foundation of Guangdong province, and the youth teacher training project of Sun Yat-sen University. 

Yangfan Yang  

Dr. Yang acquired her clinical degree of medical Master from Sun Yat-sen University in 2003. And in 2011, under the guidance of her Ph.D. advisor Prof. Minbin Yu, Dr. Yang graduated from Zhongshan Ophthalmic Center, Sun Yat-sen University. 

She has been working in the clinical medicine, teaching and science research of ophthalmology for 13 years. Her research work focus on ophthalmology, involving the following: 1) early diagnostic technology and strategy of glaucoma; 2) laser treatment used in ophthalmology and health-related quality of life in laser treatment; 3) anti-scarring in glaucoma filtration surgery and other proliferative lesions after ophthalmic surgery. 

She has published more than 40 academic papers in professional core journals, including 14 papers as the first or corresponding author (11 of which are included in SCI). She also participated in preparation and writing Clinical and Basic Research in Ophthalmology which published by People's Health Publishing House Co. LTD in 2006. 

She won the Pearl River Nova Program of Guangzhou in 2015. As a project leader, she has undertook 12 projects including National Natural Science Foundation of China, Natural Science Foundation of Guangdong Province, Science and Technology Project of Guangdong Province, Fundamental Research Funds of the State Key Laboratory of Ophthalmology, etc. She was authorized to a national invention patent as the second inventor. 

After training in Moorfields Eye Hospital NHS Foundation (London, UK) in 2014, Dr. Yang participated as a main researcher in a large single-center RCT study of laser treatment in Glaucoma from 2015. Coopered with Moorfields Eye Hospital, the study is carried out basing on the reality of China and insisting the internationalization standards, which is highly recognized. 

Dr. Yang has attended many international seminars such as WOC, WGC, APGC, APAO and gave oral presentation in APGC and APAO. She was invited to present in ARVO (Hawaii, USA) in April, 2018. 

Yiqing Li M.D., Ph.D.  

Dr. Yiqing Li received his M.D. (2006) from Sun Yat-sen University and Ph.D. (2013) from “Joint Training Program” between Sun Yat-sen University and Harvard University. He started clinical training as an ophthalmologist at Zhongshan Ophthalmic Center since 2006 (advisor: Dr. Yehong Zhuo) and did his postdoctoral fellowship at Harvard Medical School and Boston Children’s Hospital (advisor: Dr. Larry Benowitz). Due to his outstanding work, he obtained faculty-member position as an Instructor of Ophthalmology at Harvard Medical School (2016). In later 2017, he was named the “Top 100 Talents Program” from SYSU and moved back to ZOC, where he is currently an associate professor of ophthalmology. 

Dr. Li’s clinical effort is focused on patients in need of medical or surgical intervention for glaucoma. His research is directed at molecular mechanisms for neuroprotection of retinal ganglion cells and regeneration of the optic nerve, a major unsolved problem in basic research and clinical therapy for glaucoma and other degenerative optic neuropathies. The final goal of his research is to translate scientific discoveries to clinical therapies for patients. As principal investigator, Dr. Li has obtained research funding from SYSU, SKLO and ZOC in 2017. As the leading investigator, he participated in research projects supported by NIH, DoD, AMRF, NSFC, etc. He has published and co-authored 13 peer-reviewed articles, including PNAS, J Clin Invest, J Neurosci, Exp Neurol, etc. He has trained many postdoctoral fellows, graduate and undergraduate students, and has been awarded “Best Teaching Award” in 2008 and 2010 at ZOC. Under his guidance, his students has won “Best Undergraduate Thesis Award” (Harvard University, 2013；Boston College, 2015).